Why the study?
Does captopril alter baroreflex sensitivity in normotensive salt-replete male subjects?
Population
6 normotensive salt-replete male subjects
Comparison
Captopril 12.5 mg three times daily for 14 days vs Placebo
Design
Other
Follow-up
14 days
Authors
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Captopril leaves baroreflex sensitivity intact in normotensive men; confirms dissociation between ACE inhibition and autonomic modulation.
Does captopril alter baroreflex sensitivity in normotensive salt-replete male subjects?
Acute and chronic captopril therapy does not alter baroreflex sensitivity in normotensive salt-replete men, despite effective angiotensin-converting enzyme inhibition.
Kondowe et al. (1988) studied this question.
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