Why the study?
Does optical coherence tomography accurately characterize cardiac radiofrequency ablation lesions compared to untreated tissue in swine ventricular wedges?
Does optical coherence tomography accurately characterize cardiac radiofrequency ablation lesions compared to untreated tissue in swine ventricular wedges?
Optical coherence tomography can accurately distinguish radiofrequency ablation lesions from untreated myocardium in vitro, suggesting potential for real-time monitoring during ablation procedures.
Supports OCT for RFA lesion assessment in swine; leaves open translation to real-time clinical monitoring.
Currently, cardiac radiofrequency ablation (RFA) is guided by indirect signals. We demonstrate optical coherence tomography (OCT) characterization of RFA lesions within swine ventricular wedges. Untreated tissue exhibited a consistent birefringence artifact within OCT images due to the organized myocardium, which was not present in treated tissue. Birefringence artifacts were detected by filtering with a Laplacian of Gaussian (LoG) to quantify gradient strength. The gradient strength distinguished RFA lesions from untreated sites (p=5.93 x 10(-15)) with a sensitivity and specificity of 94.5% and 86.7% respectively. This study demonstrates the potential of OCT for monitoring cardiac RFA, confirming lesion formation and providing feedback to avoid complications.
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Fleming et al. (2010) studied this question.
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