What question did this study set out to answer?

To develop and evaluate a method for continuous beat-to-beat stroke volume estimation from aortic pressure pulses during non-steady state hemodynamic conditions.

July 1, 1976Circulation ResearchOpen Access

Continuous determination of beat to beat stroke volume from aortic pressure pulses in the dog.

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Why the study?

Does a new aortic pressure pulse method accurately measure beat-to-beat stroke volume compared to electromagnetic flowmeters in dogs?

Population

6 dogs with chronically implanted aortic electromagnetic flowmeters

Comparison

New method for determining beat-to-beat stroke… vs Aortic electromagnetic flowmeter measurements

Design

Preclinical

Authors

MBM. BourgeoisMayo Clinic BGBarry K. GilbertMayo Clinic GBGötz von BernuthMayo Clinic

Discussion

Member takes

Implication

Supports preclinical validation of aortic pressure pulse stroke volume assessment in dogs; leaves open human translation.

Key Points

To develop and evaluate a method for continuous beat-to-beat stroke volume estimation from aortic pressure pulses during non-steady state hemodynamic conditions.
Tested the method in 6 dogs chronically instrumented with aortic electromagnetic flowmeters during transient stroke volume changes and vasoactive drug infusions.
Modeled aortic diastolic pressure decay as an exponential function to compute systolic pressure loss from peripheral runoff and determine the uncorrected systolic pressure increment.
Calculated stroke volume from the systolic pressure increment using a conversion multiplier derived from indicator-dilution cardiac output measurements.
The method successfully determined aortic pressure-volume conversion factors across a wide range of arterial pressures during acute cardiovascular fluctuations.
Beat-to-beat stroke volume variations estimated from aortic pressure pulses agreed with electromagnetic flowmeter recordings within the margin of flowmeter measurement error.

Structured PICO

Does a new aortic pressure pulse method accurately measure beat-to-beat stroke volume compared to electromagnetic flowmeters in dogs?

Population

6 dogs with chronically implanted aortic electromagnetic flowmeters

Intervention

New method for determining beat-to-beat stroke volume from aortic pressure pulses using an exponential approximation of diastolic pressure decay

Comparator

Aortic electromagnetic flowmeter measurements

Outcome

Agreement of beat-to-beat stroke volume variations between the new method and electromagnetic flowmetersurrogate

A novel method using aortic pressure pulses can accurately estimate beat-to-beat stroke volume in a canine model, matching the accuracy of electromagnetic flowmeters.

Cite This Study

Bourgeois et al. (1976) studied this question.

synapsesocial.com/papers/6a7071b28031ec7bb1dc57e6 https://doi.org/10.1161/01.res.39.1.15

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Continuous determination of beat to beat stroke volume from aortic pressure pulses in the dog.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Continuous determination of beat to beat stroke volume from aortic pressure pulses in the dog.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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