What does this research mean for the field?

Stroke volume can be accurately estimated from the pulmonary artery pressure waveform using a pulse contour method across various hemodynamic perturbations, but accuracy degrades significantly during rapid saline infusion. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Determine whether stroke volume can be reliably estimated from pulmonary artery pressure pulse contour records under various hemodynamic perturbations.

July 1, 1974Cardiovascular Research

Estimation of stroke volume from the pulmonary artery pressure record

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: Pulse contour method applied to the pulmonary artery pressure record vs. Electromagnetic flowmeter and indicator dilution curves. Primary outcome: Correlation of stroke volume estimation.

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Key result

Pulmonary artery pulse contour stroke volume correlates well with standard measurements, except during rapid saline infusion.

Why the study?

Accurate estimation of stroke volume from pulmonary artery pressure records using a pulse contour method required validation against established measurement techniques under various physiological conditions.

Population

Series of dogs

Comparison

Pulse contour method vs electromagnetic flowmeter and indicator dilution curves

Design

Experimental physiological study

Authors

AZApostolos A. ZacharoulisMetropolitan Hospital CMC. J. MillsScottish Universities Life Sciences Alliance IGI. T. GabeMidhurst Community Hospital

Discussion

Member takes

Implication

Stroke volume estimation via pulmonary artery pulse contour warrants caution during fluid challenges; leaves open prospective validation in dynamic states.

Key Points

Determine whether stroke volume can be reliably estimated from pulmonary artery pressure pulse contour records under various hemodynamic perturbations.
Applied a pulse contour calculation method to pulmonary artery pressure tracings in canine models.
Compared pulse contour estimations against stroke volume measurements obtained via electromagnetic flowmeter and indicator dilution curves.
Evaluated accuracy across interventions including noradrenaline, isoproterenol, propranolol, hemorrhage, cardiac pacing, respiratory outflow occlusion, and rapid saline infusion.
Pulse contour estimates correlated well with reference electromagnetic flowmeter and indicator dilution measurements during drug challenges, hemorrhage, pacing, and respiratory occlusion.
Rapid saline infusion led to a significant increase in estimation error relative to reference standards.

PICO

Population

A series of dogs undergoing experimental hemodynamic changes to evaluate stroke volume estimation.

Intervention / Comparator

Pulse contour method applied to the pulmonary artery pressure record vs Electromagnetic flowmeter and indicator dilution curves

Primary Outcome

Correlation of stroke volume estimation

Limitations

Error increased significantly when saline was rapidly infused.

Cite This Study

Zacharoulis et al. (1974) studied this question. Pulse contour method applied to the pulmonary artery pressure record vs. Electromagnetic flowmeter and indicator dilution curves was evaluated on Correlation of stroke volume estimation. Estimation of stroke volume by a pulse contour method applied to the pulmonary artery pressure record correlated well with standard measurements, except during rapid saline infusion.

synapsesocial.com/papers/6ab46fed8787ea03c9f94b95 https://doi.org/10.1093/cvr/8.4.506

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Implication

Stroke volume estimation via pulmonary artery pulse contour warrants caution during fluid challenges; leaves open prospective validation in dynamic states.

Estimation of stroke volume from the pulmonary artery pressure record

Discussion

Member takes

Implication

Key Points

PICO

Limitations

Cite This Study

Estimation of stroke volume from the pulmonary artery pressure record

Discussion

Member takes

Implication

Key Points

PICO

Limitations

Cite This Study

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Also Consider