Why the study?
Does direct injection of sTNFR1 expression plasmid DNA reduce infarct size in an experimental rat model of acute myocardial infarction?
Does direct injection of sTNFR1 expression plasmid DNA reduce infarct size in an experimental rat model of acute myocardial infarction?
In vivo gene transfer of sTNFR1 reduces infarct size and cardiomyocyte apoptosis in a rat model of acute myocardial infarction, suggesting a potential novel therapeutic strategy.
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Hypothesis-generating for sTNFR1 gene therapy in experimental MI; leaves open translation to clinical practice.
Sugano et al. (2002) studied this question.
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