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July 1, 1986Nuclear Medicine Communications

In vivo stability of in vitro labelled 99Tcm-red blood cells for radionuclide determination of left ventricular ejection fractions and volumes

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Why the study?

Is in vitro labelled 99Tcm-red blood cells stable in vivo for radionuclide determination of left ventricular ejection fractions and volumes in patients with coronary artery disease?

Population

19 patients with coronary artery disease

Comparison

99Tcm-red blood cells labelled in vitro by… vs RBC labelled with 51Cr

Design

Cohort

Follow-up

1 hour after injection

Authors

HKHenning KelbækInterventional / Structural CardiologyTGT GjørupGentofte HospitalJFJan FoghCounty Hospital

Discussion

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Overview

Supports short-term serial LVEF imaging in CAD; leaves open need for patient-specific decay corrections in larger cohorts.

Structured PICO

Is in vitro labelled 99Tcm-red blood cells stable in vivo for radionuclide determination of left ventricular ejection fractions and volumes in patients with coronary artery disease?

P
Population
19 patients with coronary artery disease
I
Intervention
99Tcm-red blood cells (99Tcm-RBC) labelled in vitro by preparation with small amounts of a stannous agent
C
Comparator
RBC labelled with 51Cr (for distribution volume comparison)
O
Outcome
In vivo stability of the label (distribution volume, labelling efficiency, effective in vivo half-times)surrogate

In vitro labelled 99Tcm-RBC demonstrates high in vivo stability suitable for serial radionuclide cardiography within an hour after injection, though individual calculation of tracer decay is necessary due to inter-patient variation.

Cite This Study

Kelbæk et al. (1986) studied this question.

synapsesocial.com/papers/6a70822b35aa2c282ce1d5fahttps://doi.org/10.1097/00006231-198607000-00008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Improved Noninvasive Method for Measurement of Cardiac Output and Evaluation of Left-Sided Cardiac Valve Incompetence1989 · 1 citations
  2. 2Effect of exercise on erythrocyte count and blood activity concentration after technetium-99m in vivo red blood cell labeling.1982 · 33 citations
  3. 3The feasibility of repeated left ventricular ejection fraction analysis with sequential single-dose radionuclide ventriculography2005 · 11 citations
  4. 4Nontraumatic determination of left ventricular ejection fraction by radionuclide angiocardiography.1975 · 193 citations
  5. 5The sequential measurement of ventricular volumes and cardiac output by radionuclides1980 · 17 citations