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May 1, 1985Journal of VirologyOpen Access

Molecular cloning and partial sequencing of hepatitis A viral cDNA

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Population

Hepatitis A virus purified from infected monkey kidney cell cultures

Design

Preclinical

Authors

DLDavid L. LinemeyerMerck & Co., Inc., Rahway, NJ, USA (United States)JMJohn G. MenkeLa Roche CollegeAMAntonia Martín-GallardoLawrence Livermore National Laboratory

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Implication

Provides initial HAV genomic sequence data; leaves open complete characterization and therapeutic applications.

Structured PICO

P
Population
Hepatitis A virus purified from infected monkey kidney cell cultures
I
Intervention
Molecular cloning and sequencing of viral cDNA
O
Outcome
Generation of a composite map representing at least 97% of the viral genome and nucleotide sequence of 3,054 base pairs

The study successfully cloned and partially sequenced the hepatitis A viral genome, identifying key structural protein sequences.

Cite This Study

Linemeyer et al. (1985) studied this question.

synapsesocial.com/papers/6a708f6c8031ec7bb1dc6d56https://doi.org/10.1128/jvi.54.2.247-255.1985
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Taxonomic Classification of Hepatitis A Virus1983 · 93 citations
  2. 2Molecular cloning and characterization of hepatitis A virus cDNA.1983 · 140 citations
  3. 3Evidence that the genome of hepatitis A virus consists of single-stranded RNA1981 · 30 citations
  4. 4Restricted replication of human hepatitis A virus in cell culture: intracellular biochemical studies1981 · 43 citations
  5. 5Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome.1981 · 555 citations