The study demonstrates that Coxsackievirus A16 strains circulating in Yamagata, Japan since the end of the 20th century predominantly belong to the third genogroup.
Third genogroup predominance in Yamagata CVA16 strains; extends local genotyping data but leaves broader surveillance and vaccine implications open.
To clarify the longitudinal molecular epidemiology of coxsackievirus A16, phylogenetic analysis based on the VP1 region of 220 isolates in Yamagata, Japan was performed. The resultant phylogenetic tree indicates that the Yamagata isolates and reference strains can be readily genotyped into three genogroups, and 0, 12 and 208 isolates belonged to the first, second, and third genogroups, respectively. The first genogroup includes only the prototype strain, the second strains that had disappeared by the end of the 20th century and the third comprises those that have been circulating since then in local communities, such as Yamagata.
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Mizuta et al. (2013) studied this question.
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