Key result
Sequential isolates of Coxsackie A16 virus from 1951 to 1970 in Japan were classified into prototype strain-like and epidemic strain-like groups based on serological and biological comparisons.
Observational
The study identified that Coxsackie A16 virus isolates from 1964-1970 in Japan evolved into two distinct antigenic groups, explaining the emergence of the 1970 epidemic strain.
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Antigenic shifts in historical Coxsackie A16 isolates may signal epidemic risk; leaves open need for ongoing modern surveillance.
Biological and serological comparisons of sequential isolates of Coxsackie A16 virus (Cox A16) in 1951 through 1970 were made to elucidate the mode of appearance of the mutant which caused a nationwide epidemic of hand‐foot‐and‐mouth disease (HFMD) in 1970. Most strains isolated from feces of healthy children in 1964, 1966 and 1967 were serologically similar to the prototype strain isolated in 1951. However, some strains isolated from these healthy children in 1966 and 1967 were serologically and biologically related more closely to the epidemic strain isolated in 1970. Thus sequential isolates of Cox A16 could be roughly classified into two groups, i.e., the prototype strain‐like and the epidemic strain‐like groups.
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Fujimiya et al. (1974) conducted an observational in Hand-foot-and-mouth disease (HFMD). Coxsackie A16 virus isolates was evaluated on Biological and serological classification of strains. Sequential isolates of Coxsackie A16 virus from 1951 to 1970 in Japan were classified into prototype strain-like and epidemic strain-like groups based on serological and biological comparisons.
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