November 10, 2015British Journal of CancerOpen Access

Age as an independent prognostic factor for survival of localised synovial sarcoma patients

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Why the study?

Does age at diagnosis affect overall survival in patients with localized synovial sarcoma?

Population

461 patients with localized synovial sarcoma at diagnosis, median age 38.0 years, from the Netherlands…

Design

Cohort

Follow-up

up to 10 years

Authors

MVMyrella VlenterieGelre Hospitals VHVincent K.Y. HoUniversity Medical Center Utrecht SKSuzanne E. J. KaalRadboud University Nijmegen

Discussion

Member takes

Implication

Older age independently predicts poorer survival in localised synovial sarcoma; extends prior observations but leaves open optimal age-adapted strategies.

Structured PICO

Does age at diagnosis affect overall survival in patients with localized synovial sarcoma?

Population

461 patients with localized synovial sarcoma at diagnosis, median age 38.0 years, from the Netherlands Cancer Registry.

Comparator

Different age groups (children <18 years, adolescents and young adults 18-34 years, adults 35-64 years, and elderly ≥65 years)

Outcome

Overall survival (OS)hard clinical

Age at diagnosis is an independent prognostic factor for overall survival in localized synovial sarcoma, with older patients having significantly worse outcomes regardless of tumor size, site, or treatment.

Limitations

Retrospective character of data collection
Long period over which data were assembled, during which molecular diagnostics were introduced and improved
Large proportion of pathology reports lacked information on synovial sarcoma subtype
Inadequate reporting of residual disease status in more than half of surgical resections
Lack of SYT-SSX translocation status in the database

Cite This Study

Vlenterie et al. (2015) studied this question.

synapsesocial.com/papers/6a70a8c7febe604dd7096e35 https://doi.org/10.1038/bjc.2015.375

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Implication

Older age independently predicts poorer survival in localised synovial sarcoma; extends prior observations but leaves open optimal age-adapted strategies.

Age as an independent prognostic factor for survival of localised synovial sarcoma patients

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Age as an independent prognostic factor for survival of localised synovial sarcoma patients

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider