Population
Platelets evaluated in static and blood flow conditions over collagen matrix
Comparison
Inhibition of ERK2 phosphorylation by PD 98059… vs Uninhibited control conditions
Design
Preclinical
Authors
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No clinical translation yet from this animal model; leaves open context-specific MAPK targeting for human thrombosis.
ERK2 and p38 MAP kinases have complementary, shear stress-dependent roles in regulating platelet adhesion to collagen.
Mazharian et al. (2005) studied this question.
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