Population
In vitro model studying the 5' noncoding region of the poliovirus genome and cellular proteins
Design
Preclinical
Authors
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Hypothesis-generating for redox-sensitive poliovirus regulation; leaves open relevance to human pathogenesis or therapy.
Demonstrates that a cellular 50-kDa protein interacts with the poliovirus 5' noncoding region in an oxidation-reduction sensitive manner, potentially regulating viral gene expression.
Najita et al. (1990) studied this question.
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