Primary hyperaldosteronism should be considered in patients presenting with hypertension, hypokalemia, and periodic paralysis.
Alerts clinicians to primary aldosteronism in hypokalemic hypertension with paralysis; single case leaves open optimal screening thresholds.
Primary hyperaldosteronism is found in up to 13% of patients with hypertension. This article describes a patient with hypokalemia, hypertension, and periodic paralysis that were caused by primary hyperaldosteronism. Plasma aldosterone concentration to plasma renin activity ratio is a common screening test, and adrenal vein sampling can be performed to determine which gland is overproducing aldosterone. Treatment with mineralocorticoid receptor antagonists or adrenalectomy gives similar reductions in BP.
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Caroline S. Fox (2016) studied this question.
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