Why the study?
Do antagonists of the renin-angiotensin system alter the cardiovascular response to lower-body subatmospheric pressure in anaesthetized cats?
Population
Anaesthetized cats
Comparison
Antagonists of the renin-angiotensin system vs Baseline
Design
Preclinical
Authors
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RAS inhibition exaggerates BP fall and impairs recovery during LBNP in cats; leaves open human relevance.
Do antagonists of the renin-angiotensin system alter the cardiovascular response to lower-body subatmospheric pressure in anaesthetized cats?
Angiotensin interacts with the sympathetic nervous system to maintain arterial blood pressure during lower-body negative pressure, even at concentrations with no direct effect on blood pressure.
Adigun et al. (1980) studied this question.
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