Effect of Atenolol plus Amlodipine on blood sugar level and lipid profile in patients of essential hypertensive patients

Objectives: Study was conducted to evaluation effect of Atenolol plus Amlodipine on blood glucose level and lipid profile in essential hypertensive patients. Materials and Methods: A Prospective Observational study was conducted at tertiary care teaching hospital which included a total 165 patients with essential hypertension. The demographic and baseline data, Random blood sugar level and lipid profile of the patients were recorded. After baseline investigation of each parameter of the patients were subsequently monitored and reassessed at 4th week, 8th week and 12th weeks of interval during each follow-up. Results: Total 165 Patients were receiving Atenolol plus Amlodipine showed a significant increase Random blood sugar level and lipid profile (Total cholesterol, Total triglyceride, Low-density lipoprotein, Very-low density lipoprotein, and High density lipoprotein) except HDL (High density lipoprotein) which was significant reduced at the end of 4th, 8th and 12th weeks of interval as compared to their baseline data. Conclusion: The Finding of the present study was that the effect of Atenolol plus Amlodipine on Random blood sugar level, Total cholesterol, Total triglyceride, Low-density lipoprotein, Very-low density lipoprotein, significant increase (p-value <0.0001) at the end of 12 week of treatment therapy from baseline data. HDL was significant reduced (p-value <0.0001) with the treatment of Atenolol plus Amlodipine at the end of treatment from baseline data.