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December 1, 1983AJP Renal Physiology

Afferent arteriolar diameter in DOCA-salt and two-kidney one-clip hypertensive rats

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Population

Normal and uninephrectomized control rats, chronic DOCA-salt, post-DOCA, chronic two-kidney one-clip…

Comparison

Induction of hypertension via DOCA-salt or… vs Normal and uninephrectomized control rats

Design

Preclinical

Follow-up

up to 50 days

Authors

BIB. M. IversenHaukeland University HospitalLMLars MørkridOslo University HospitalJOJarle OfstadOslo University Hospital

Discussion

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Implication

Indicates angiotensin-independent afferent arteriolar constriction in experimental hypertension; extends mechanistic insights but leaves open clinical relevance.

Structured PICO

P
Population
Normal and uninephrectomized control rats, chronic DOCA-salt (DOCA), post-DOCA (p-DOCA), chronic two-kidney one-clip (2K-1C) hypertensive rats, and post-two-kidney one-clip (p-2K-1C) normotensive rats
I
Intervention
Induction of hypertension via DOCA-salt or two-kidney one-clip (2K-1C) models
C
Comparator
Normal and uninephrectomized control rats
O
Outcome
Afferent arteriolar diameter (dAA) measured by the microsphere methodsurrogate

Chronic renal DOCA-salt hypertension constricts the afferent arteriole via angiotensin-independent mechanisms, while autoregulatory dilatation is maintained in clipped kidneys.

Cite This Study

Iversen et al. (1983) studied this question.

synapsesocial.com/papers/6a70d27ae5469ee92be17ecfhttps://doi.org/10.1152/ajprenal.1983.245.6.f755
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Afferent arteriolar responsiveness to altered perfusion pressure in renal hypertension.1990 · 41 citations
  2. 2Alterations in the microvasculature of one-kidney, one-clip hypertensive rats1987 · 47 citations
  3. 3Angiotensin II-induced calcium signaling in the afferent arteriole from rats with two-kidney, one-clip hypertension2006 · 31 citations
  4. 4Histometric assessment of renal arterioles during DOCA and post-DOCA hypertension and hydralazine treatment in rats1989 · 5 citations
  5. 5Selective distribution of medial thickening in the renal vessels in experimental hypertension1994 · 7 citations