Key result
DOCA-salt hypertension in cats causes small renal artery medial thickening in ~50% of cases.
Why the study?
The direct effects and distribution of medial thickening in the renal arterial tree due to chronic hypertension were not well characterized in experimental hypertension.
Comparison
One-kidney DOCA-salt hypertension vs uninephrectomized without DOCA/salt and intact without DOCA/salt
Design
Pathological and morphometrical study in experimental hypertension
Follow-up
3 weeks to 4 months
Authors
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No immediate clinical implications for human hypertension; leaves open whether autoregulatory remodeling occurs in clinical renal arteriolosclerosis.
Absolute Event Rate: 50% vs 0%
Chronic hypertension in a feline model causes preferential medial thickening in small renal arteries and arterioles, likely due to autoregulatory mechanisms.
Chen et al. (1994) studied Hypertension (n=21). One-kidney DOCA-salt hypertension vs. Uninephrectomy alone or DOCA-salt without uninephrectomy was evaluated on Significant medial thickening of the right renal arterial tree (diameter <40 μm). One-kidney DOCA-salt hypertension in cats caused significant medial thickening of renal arteries <40 μm in 50% of cases, specifically when mean blood pressure increased >34.6 mmHg.
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