Evidence for Involvement of the Type 1 Angiotensin II Receptor Locus in Essential Hypertension
Why the study?
Is the type 1 angiotensin II receptor (AT1) gene locus associated with essential hypertension in the Finnish population?
Population
329 Finnish hypertensive twins and their affected siblings from 142 families, and an independent series of…
Comparison
Genetic linkage and association analysis of the… vs Normotensive controls (for the association study).
Design
Case-control
Authors
Discussion
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Member takes
Overview
AT1 locus variants may influence hypertension risk in Finns; hypothesis-generating and should not change practice.
Structured PICO
Is the type 1 angiotensin II receptor (AT1) gene locus associated with essential hypertension in the Finnish population?
P
Population
329 Finnish hypertensive twins and their affected siblings from 142 families (linkage study), and an independent series of 50 hypertensive cases and 122 normotensive controls (association study).
I
Intervention
Genetic linkage and association analysis of the type 1 angiotensin II receptor (AT1) locus and other renin-angiotensin system genes.
C
Comparator
Normotensive controls (for the association study).
O
Outcome
Genetic linkage (LOD score) and allelic association with essential hypertension.surrogate
A common genetic variant of the AT1 gene locus influences the risk of essential hypertension in the Finnish population.
Cite This Study
Kainulainen et al. (1999) studied this question.