Why the study?
Does perindopril improve cardiac performance and myocardial energy efficiency in a rat model of aortic regurgitation?
Population
30 male Sprague-Dawley rats (20 with induced aortic regurgitation, 10 sham-operated controls)
Comparison
Perindopril 5 mg/kg/d initiated 3 days after… vs Untreated rats with aortic regurgitation and…
Design
Preclinical
Follow-up
100 days
Authors
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Perindopril may preserve energetics in rat aortic regurgitation; leaves open translation to human disease.
Does perindopril improve cardiac performance and myocardial energy efficiency in a rat model of aortic regurgitation?
Perindopril improves cardiac performance and myocardial energy efficiency in a rat model of chronic aortic regurgitation, potentially mediated by suppression of uncoupling protein-2.
Murakami et al. (2002) studied this question.
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