Why the study?
Does angiotensin I-converting enzyme inhibition improve arterial structure and stiffness in hypertension?
Population
Hypertensive rats and humans with hypertension
Comparison
Angiotensin I-converting enzyme (ACE) inhibition vs Other antihypertensive agents
Design
Review
Authors
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May support ACE inhibitor preference for vascular remodeling in hypertension; leaves open outcome benefits in prospective trials.
Does angiotensin I-converting enzyme inhibition improve arterial structure and stiffness in hypertension?
ACE inhibitors reverse structural vascular changes and improve large artery compliance in hypertension, which may contribute to blood pressure reduction and improved pulse pressure amplification.
Safar et al. (2008) studied this question.
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