What is the clinical evidence from this study?

Study design: Review. Population: Hypertension. Intervention: Angiotensin-converting enzyme inhibitors.

What question did this study set out to answer?

Examine how structural remodeling of blood vessels perpetuates hypertension and evaluate the therapeutic potential of reversing these changes via ACE inhibition.

January 1, 1991Journal of Cardiovascular Pharmacology

Angiotensin-Converting Enzyme Inhibition and Vascular Structure in Hypertension

View Full Paper

Ask AI

Bookmark

Key result

Angiotensin-converting enzyme inhibitors and the paracrine renin-angiotensin system may play a role in reversing vascular remodeling associated with hypertension.

Design

Review

Authors

GGGary H. GibbonsGeneral / Preventive / Lipids

Discussion

Member takes

Implication

May support ACE inhibitor benefits beyond BP control in hypertension; hypothesis-generating and leaves open need for prospective confirmation.

Key Points

Examine how structural remodeling of blood vessels perpetuates hypertension and evaluate the therapeutic potential of reversing these changes via ACE inhibition.
Narrative synthesis of vascular structural changes in hypertensive states based on Folkow's hemodynamic remodeling model.
Analysis of autocrine and paracrine renin-angiotensin pathways and local growth factors regulating vascular media-to-lumen architecture.
Hypertensive remodeling reduces luminal area and thickens the vascular medial layer, amplifying vasoconstrictor reactivity and promoting target-organ damage.
Targeting local tissue renin-angiotensin systems with ACE inhibitors presents a dual clinical benefit by lowering systemic pressure and reversing adverse vascular structural changes.

Structured PICO

Intervention

Angiotensin-converting enzyme inhibitors

The review highlights the potential of ACE inhibitors to not only normalize blood pressure but also reverse vascular remodeling in hypertension.

Cite This Study

Gary H. Gibbons (1991) conducted a review in Hypertension. Angiotensin-converting enzyme inhibitors was evaluated. Angiotensin-converting enzyme inhibitors and the paracrine renin-angiotensin system may play a role in reversing vascular remodeling associated with hypertension.

synapsesocial.com/papers/6a9dce2889d8ba747d19cb4c https://doi.org/10.1097/00005344-199100180-00005

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

May support ACE inhibitor benefits beyond BP control in hypertension; hypothesis-generating and leaves open need for prospective confirmation.

Angiotensin-Converting Enzyme Inhibition and Vascular Structure in Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Angiotensin-Converting Enzyme Inhibition and Vascular Structure in Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider