Acetyl-Leu-Ala-Ala-(N,N'-dimethylglutaminal) is a selective, reversible, slow-binding inhibitor of Hepatitis A virus 3C proteinase that forms a thiohemiacetal adduct with the enzyme.
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May guide selective HAV 3C inhibitor design; leaves open in vivo efficacy and clinical translation.
Malcolm et al. (1995) studied this question.
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