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July 1, 2001The Journal of PhysiologyOpen Access

Differential regulation of Ca2+‐activated Cl− currents in rabbit arterial and portal vein smooth muscle cells by Ca2+‐calmodulin‐dependent kinase

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Population

Smooth muscle cells isolated from rabbit pulmonary and coronary artery as well as rabbit portal vein

Comparison

CaMKII inhibitor KN-93, autocamtide-2-related… vs Inactive analogue KN-92 or baseline conditions

Design

Preclinical

Authors

IGIain A. GreenwoodSt George's, University of LondonJLJonathan LedouxUniversité de MontréalNLNormand LeblancUniversity of Nevada, Reno

Discussion

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Implication

Tissue-specific CaMKII effects on vascular Cl channels leave open human relevance; hypothesis-generating for targeted vascular therapies.

Structured PICO

P
Population
Smooth muscle cells isolated from rabbit pulmonary (PA) and coronary artery (CA) as well as rabbit portal vein (PV)
I
Intervention
CaMKII inhibitor KN-93 (5 microM), autocamtide-2-related CaMKII inhibitory peptide (ARIP), or constitutively active CaMKII (30 nM)
C
Comparator
Inactive analogue KN-92 or baseline conditions
O
Outcome
Amplitude and kinetics of Ca(2+)-activated chloride currents (I(Cl(Ca)))surrogate

Regulation of Ca(2+)-dependent Cl(-) channels by CaMKII differs significantly between arterial and portal vein smooth muscle cells.

Cite This Study

Greenwood et al. (2001) studied this question.

synapsesocial.com/papers/6a70e05ef44fa9f079de9b30https://doi.org/10.1111/j.1469-7793.2001.00395.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Macroscopic K+ currents in single smooth muscle cells of the rabbit portal vein.1989 · 89 citations
  2. 2Inactivation of calcium-activated chloride channels in smooth muscle by calcium/calmodulin-dependent protein kinase1997 · 108 citations
  3. 3Inhibition of CaM kinase II activation and force maintenance by KN-93 in arterial smooth muscle2000 · 85 citations
  4. 4Activation of calcium-dependent chloride channels in rat parotid acinar cells.1996 · 152 citations
  5. 5Some properties of the smooth muscle of rabbit portal vein1968 · 132 citations