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January 12, 1971Acta Medica Scandinavica

Fibrinolytic Treatment in Acute Myocardial Infarction

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Why the study?

Does streptokinase treatment reduce mortality in patients with acute myocardial infarction?

Population

426 patients admitted with symptoms of acute myocardial infarction across four hospitals

Comparison

Streptokinase (SK), 600,000 IU or more vs Control group receiving standard care without…

Design

Cohort

Follow-up

six weeks

Authors

RHR HeikinheimoUniversity of TurkuPAP. AhrenbergTurku University HospitalHHH HonkapohjaTurku University Hospital

Discussion

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Implication

No mortality benefit observed with streptokinase; leaves open efficacy in acute MI pending randomized trials.

Structured PICO

Does streptokinase treatment reduce mortality in patients with acute myocardial infarction?

P
Population
426 patients admitted with symptoms of acute myocardial infarction across four hospitals
I
Intervention
Streptokinase (SK), 600,000 IU or more
C
Comparator
Control group receiving standard care without streptokinase
O
Outcome
Total mortality at six weekshard clinical

In this early study, streptokinase treatment did not demonstrate a mortality benefit at six weeks in patients with acute myocardial infarction.

Cite This Study

Heikinheimo et al. (1971) studied this question.

synapsesocial.com/papers/6a70f205fe4101aa97e061e5https://doi.org/10.1111/j.0954-6820.1971.tb04333.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced In-Hospital Mortality Following Intracoronary Streptokinase Treatment of Acute Myocardial Infarction1987 · 2 citations
  2. 2Effectiveness of intravenous streptokinase on infarct size and left ventricular function in acute myocardial infarction, prospective and randomized study1987 · 19 citations
  3. 3The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Randomized Trial.1988 · 244 citations
  4. 4Fibrinolytic therapy in patients with ST-segment elevation myocardial infarction: Accelerated versus standard Streptokinase infusion regimen2017 · 10 citations
  5. 5Efficacy of a New Accelerated Streptokinase Regime in Acute Myocardial Infarction: A Double Blind Randomized Clinical Trial2011 · 10 citations