Why the study?
Does increasing stimulation frequency exert a positive inotropic effect on the fetal lamb heart?
Population
Fetal lamb hearts (isolated ventricular myocardium and n=7 chronically instrumented fetal lambs)
Comparison
Paired electrical stimulation and increasing… vs Adult ventricular myocardium and…
Design
Preclinical
Authors
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Frequency-dependent inotropy in fetal myocardium; hypothesis-generating and leaves open translation to human neonates or pacing strategies.
Does increasing stimulation frequency exert a positive inotropic effect on the fetal lamb heart?
Increases in the frequency of contraction exert a significant positive inotropic effect on the fetal heart, despite reduced poststimulation potentiation compared to adults.
Kirkpatrick et al. (1975) studied this question.
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