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June 1, 1986HypertensionOpen Access

Is low-dose hydrochlorothiazide effective?

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Why the study?

Does hydrochlorothiazide added to nadolol reduce blood pressure in patients with pretreatment diastolic blood pressure between 95 and 109 mm Hg?

Population

13 patients with pretreatment diastolic blood pressure between 95 and 109 mm Hg

Comparison

Hydrochlorothiazide at 12.5 mg, 25 mg, or 50 mg… vs Placebo of hydrochlorothiazide added to nadolol…

Design

RCT, double-blind

Follow-up

3 weeks per regimen

Authors

PMPatrick MageeInterventional CardiologyEFE. D. FreisBoston Medical Center

Discussion

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Implication

Low-dose hydrochlorothiazide adds no benefit to nadolol; confirms dose-dependent synergy is required for combination antihypertensive efficacy.

Structured PICO

Does hydrochlorothiazide added to nadolol reduce blood pressure in patients with pretreatment diastolic blood pressure between 95 and 109 mm Hg?

P
Population
13 patients with pretreatment diastolic blood pressure between 95 and 109 mm Hg
I
Intervention
Hydrochlorothiazide at 12.5 mg, 25 mg, or 50 mg daily added to nadolol 80 mg/day for 3 weeks per regimen (with a 6-week extension for the 12.5 mg dose)
C
Comparator
Placebo of hydrochlorothiazide added to nadolol 80 mg/day
O
Outcome
Reduction in systolic and diastolic blood pressuresurrogate

In patients treated with nadolol, low-dose hydrochlorothiazide (12.5 mg/day) does not significantly reduce blood pressure, suggesting higher doses (50 mg/day) are required for combined efficacy.

Cite This Study

Magee et al. (1986) studied this question.

synapsesocial.com/papers/6a712b263ce530166bc306a2https://doi.org/10.1161/01.hyp.8.6_pt_2.ii135

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Treatment of Essential Hypertension with Nadolol and Hydrochlorothiazide: A Two-Year Follow-Up1982 · 1 citations
  2. 2Treatment of Ambulatory Hypertensives With Nebivolol or Hydrochlorothiazide Alone and in Combination1994 · 43 citations
  3. 3Treatment of hypertension in the elderly: I. Blood pressure and clinical changes. Results of a Department of Veterans Affairs Cooperative Study.1990 · 86 citations
  4. 4Relation Between Low Dose of Hydrochlorothiazide, Antihypertensive Effect and Adverse Effects1994 · 33 citations
  5. 5Antihypertensive and Biochemical Effects of Different Doses of Hydrochlorothiazide Alone or in Combination with Triamterene1986 · 35 citations