Population
21 awake dogs (12 with renal hypertension, 9 normotensive controls)
Comparison
Renal hypertension model, with evaluation at… vs Normotensive control dogs
Design
Preclinical
Authors
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Animal findings link vasa vasorum impairment to hypertensive aortopathy; leaves open human relevance and therapeutic targeting.
Chronic hypertension limits the vasodilator capacity of vasa vasorum in the thoracic aorta, which may contribute to medial necrosis and aortic dissection.
Marcus et al. (1985) studied this question.
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