Population
Rat models of experimental hypertension
Comparison
Renal ablation or deoxycorticosterone-saline… vs Aortic ligature or stroke-prone spontaneously…
Design
Preclinical
Follow-up
4 to 8 weeks
Authors
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Suggests preglomerular resistance modulates glomerular injury in hypertensive rats; leaves open translation to clinical hypertension management.
In experimental rat models of hypertension, increased preglomerular resistance appears to protect glomeruli from injury, whereas decreased resistance with increased pressure and/or flow is injurious.
Olson et al. (1986) studied this question.
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