May 1, 1992CirculationOpen Access

In vivo lymphocyte-mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis.

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Population

Lewis rats

Design

Preclinical

Authors

MKMakoto KodamaKanazawa University YMY MatsumotoOkayama University MFM FujiwaraSophia University

Discussion

Member takes

Implication

Supports cellular over humoral mediation in experimental myocarditis; leaves open relevance to human disease.

Structured PICO

Population

Lewis rats (naive recipient rats and donor rats immunized with human cardiac myosin fraction in complete Freund's adjuvant)

Intervention

Adoptive transfer of cellular factors (spleen cells or lymph node cells cultured for 3 days with 1 microgram/ml concanavalin A) or humoral factors (fresh sera or 15.75 mg immunoglobulin fraction)

Outcome

Elicitation of severe myocarditis (macroscopic features and histological findings including myocardial necrosis, inflammatory cell infiltration, and multinucleated giant cells)surrogate

This preclinical study provides direct evidence that experimental autoimmune myocarditis is mediated by cellular (lymphocyte) rather than humoral factors.

Cite This Study

Kodama et al. (1992) studied this question.

synapsesocial.com/papers/6a7189d3fe4101aa97e09be7 https://doi.org/10.1161/01.cir.85.5.1918

Topics

Myocarditis

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In vivo lymphocyte-mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

In vivo lymphocyte-mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider