October 1, 1993Endocrinology

Locally produced angiotensin II induces ovulation by stimulating prostaglandin production in in vitro perfused rabbit ovaries

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Structured PICO

Population

in vitro perfused rabbit ovaries

Intervention

Angiotensin II (100 or 10 micrograms at 2-h intervals), with or without saralasin (2 x 10(-6) M), human CG (hCG), indomethacin, or staurosporine (10(-6) M)

Comparator

control ovaries perfused with medium alone

Outcome

ovarian steroidogenesis (progesterone, estradiol) and production of prostaglandin (PGE2, PGF2 alpha), ovulation, and oocyte maturationsurrogate

Locally produced angiotensin II plays a direct role in ovarian estradiol and prostaglandin production, and may induce ovulation via prostaglandin stimulation in rabbits.

Discussion

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Implication

Highlights local angiotensin II actions in rabbit ovulation; leaves open translation to human reproductive or cardiovascular physiology.

Cite This Study

Yasuhide Yoshimura (1993) studied this question.

synapsesocial.com/papers/6a71aa55ce524a4339c516d1 https://doi.org/10.1210/en.133.4.1609

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Locally produced angiotensin II induces ovulation by stimulating prostaglandin production in in vitro perfused rabbit ovaries

Structured PICO

Discussion

Implication

Cite This Study

Locally produced angiotensin II induces ovulation by stimulating prostaglandin production in in vitro perfused rabbit ovaries

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider