Why the study?
Does saralasin reduce the number of ovulated oocytes in immature rats?
Population
Immature rats in which follicle development and ovulation had been induced with pregnant mare serum…
Design
Preclinical
Follow-up
17 to 20 hours after hCG administration
Authors
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Hypothesis-generating for RAS modulation of ovulation; human studies required before considering contraceptive or profertility applications.
Does saralasin reduce the number of ovulated oocytes in immature rats?
Angiotensin II plays a direct, obligate role in ovulation, suggesting potential contraceptive and profertility applications for renin-angiotensin system modulators.
Pellicer et al. (1988) studied this question.
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