Population
In vitro perfused rabbit ovaries
Comparison
Angiotensin II, with or without saralasin, human… vs Control ovaries perfused with medium alone
Design
Preclinical
Authors
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No immediate clinical implications for fertility; leaves open translational relevance of local Ang II in human ovulation.
In a rabbit model, locally produced angiotensin II plays a direct role in ovarian estradiol and prostaglandin production, acting as an intermediary in gonadotropin-stimulated ovulation.
Yoshimura et al. (1993) studied this question.
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