Key result
A hypocaloric very-low-carbohydrate diet transiently reduced endothelial function at 5-7 days compared to a Mediterranean diet (P=0.007 for interaction), returning to baseline at 2 months.
Why the study?
Does a hypocaloric very-low-carbohydrate diet compared to a Mediterranean diet affect endothelial function in overweight/obese healthy women?
Population
20 overweight/obese but otherwise healthy women (BMI: 27-34.9 kg/m2; age 30-50 years)
Comparison
Hypocaloric very-low-carbohydrate diet for 2… vs Hypocaloric Mediterranean diet for 2 months
Design
RCT, randomized, open
Follow-up
2 months
Authors
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Short-term endothelial monitoring warranted with very-low-carbohydrate diets; extends RCT evidence on diet-specific vascular effects in obesity.
RCT (n=20)
Open-label
Does a hypocaloric very-low-carbohydrate diet compared to a Mediterranean diet affect endothelial function in overweight/obese healthy women?
p-value: p=0.007
A very-low-carbohydrate diet may acutely impair endothelial function and increase inflammation compared to a Mediterranean diet in the short term, despite producing greater weight loss at 2 months.
Buscemi et al. (2009) conducted an RCT in Overweight/obesity (n=20). Hypocaloric very-low-carbohydrate diet vs. Hypocaloric Mediterranean diet was evaluated on Endothelial function measured by brachial artery flow-mediated dilation (FMD) (p=0.007). A hypocaloric very-low-carbohydrate diet transiently reduced endothelial function at 5-7 days compared to a Mediterranean diet (P=0.007 for interaction), returning to baseline at 2 months.
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