Key result
A 6-week low-carbohydrate diet, with or without caloric restriction, improved microvascular (p≤0.02) but not macrovascular endothelial function (p=0.7) in women with obesity.
Why the study?
Evidence on the effect of a low-carbohydrate diet on endothelial function was conflicting and confounded by the provision of caloric restriction.
Does a low-carbohydrate diet with or without caloric restriction improve macrovascular and microvascular endothelial function in women with obesity?
Comparison
Low-carbohydrate diet with caloric restriction vs low-carbohydrate diet without caloric restriction
Design
Randomized study
Follow-up
6 weeks
Authors
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LC diet may improve microvascular endothelial function independent of CR in obese women; leaves open macrovascular effects and need for larger trials.
RCT (n=21)
Does a low-carbohydrate diet with or without caloric restriction improve macrovascular and microvascular endothelial function in women with obesity?
p-value: p=0.7 for macrovascular, ≤0.02 for microvascular
A 6-week low-carbohydrate diet improves microvascular but not macrovascular endothelial function in women with obesity, independent of caloric restriction.
Hwang et al. (2020) conducted an RCT in Obesity (n=21). Low-carbohydrate diet with caloric restriction vs. Low-carbohydrate diet without caloric restriction was evaluated on Macrovascular and microvascular endothelial function (p=0.7 for macrovascular, ≤0.02 for microvascular). A 6-week low-carbohydrate diet, with or without caloric restriction, improved microvascular (p≤0.02) but not macrovascular endothelial function (p=0.7) in women with obesity.
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