Key result
A very low carbohydrate diet impaired flow-mediated dilatation compared to a low fat diet (decreased to 3.7% vs 5.5%; P=0.045) over 52 weeks, despite similar weight loss.
Why the study?
Does an energy restricted very low carbohydrate, high saturated fat diet improve endothelial function compared to a high carbohydrate, low fat diet in overweight or obese patients?
Population
n=49 overweight or obese patients, mean age 50.0 ± 1.1 years, BMI 33.7 ± 0.6 kg m−2
Comparison
Energy restricted very low carbohydrate, high… vs Energy restricted isocaloric high carbohydrate…
Design
RCT, randomized
Follow-up
52 weeks
Authors
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Very low carbohydrate diet impairs endothelial function; warrants caution in at-risk patients and challenges vascular benefits of carbohydrate restriction beyond weight loss.
RCT (n=49)
randomized
Does an energy restricted very low carbohydrate, high saturated fat diet improve endothelial function compared to a high carbohydrate, low fat diet in overweight or obese patients?
Absolute Event Rate: 3.7% vs 5.5%
p-value: p=0.045
A very low carbohydrate, high saturated fat diet impairs flow-mediated dilatation compared to a low fat diet despite similar weight loss, suggesting potential detrimental effects on endothelial function.
Wycherley et al. (2009) conducted an RCT in Overweight or obese (n=49). Very low carbohydrate, high saturated fat diet vs. Isocaloric high carbohydrate, low fat diet was evaluated on Flow-mediated dilatation (FMD) (p=0.045). A very low carbohydrate diet impaired flow-mediated dilatation compared to a low fat diet (decreased to 3.7% vs 5.5%; P=0.045) over 52 weeks, despite similar weight loss.
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