May 1, 1989Journal of Pharmacy and Pharmacology

The Effect of Diazepam on Ventricular Automaticity Induced by a Local Injury. Evidence of Involvement of “Peripheral Type” Benzodiazepine Receptors

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Why the study?

Does diazepam reduce ectopic cardiac automaticity in a rat model of local ventricular injury?

Structured PICO

Does diazepam reduce ectopic cardiac automaticity in a rat model of local ventricular injury?

Population

Rat isolated right ventricle with local injury producing sustained abnormal rhythm

Intervention

Diazepam (30-50 microM) alone or in combination with GABA, picrotoxin, RO 15-1788, PK 11195, diltiazem, or Bay K 8644

Comparator

Baseline abnormal rhythm

Outcome

Ectopic cardiac automaticity (sustained abnormal rhythm)surrogate

Diazepam reduces ectopic cardiac automaticity in a rat model via a calcium-dependent mechanism partially mediated by peripheral-type benzodiazepine receptors.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports diazepam antiarrhythmic effects in rat ventricular injury model; leaves open any clinical translation or human arrhythmia trials.

Cite This Study

Ruiz et al. (1989) studied this question.

synapsesocial.com/papers/6a71bc842163a0a01bc5c0ea https://doi.org/10.1111/j.2042-7158.1989.tb06462.x

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Implication

Supports diazepam antiarrhythmic effects in rat ventricular injury model; leaves open any clinical translation or human arrhythmia trials.

The Effect of Diazepam on Ventricular Automaticity Induced by a Local Injury. Evidence of Involvement of “Peripheral Type” Benzodiazepine Receptors

Structured PICO

Discussion

Implication

Cite This Study

The Effect of Diazepam on Ventricular Automaticity Induced by a Local Injury. Evidence of Involvement of “Peripheral Type” Benzodiazepine Receptors

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider