July 9, 1968Proceedings of the Royal Society B Biological Sciences

The influence of internal sodium on the behaviour of motor nerve endings

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Population

Frog neuromuscular junction model

Design

Preclinical

Authors

RBR. I. BirksUniversity of Leeds MCM.W. CohenMcGill University

Discussion

Member takes

Implication

Hypothesis-generating in animal models; leaves open any relevance to digoxin use in patients.

Structured PICO

Population

Frog neuromuscular junction model

Intervention

Digoxin in varying extracellular fluid ionic compositions (sodium, chloride, potassium, calcium, and magnesium variations)

Outcome

Electrophysiological behavior of motor nerve endings (e.p.p. amplitude, m.e.p.p. frequency, conduction block)surrogate

Digoxin's effects on motor nerve endings appear to be driven by intracellular sodium accumulation and modified by potassium loss, suggesting a mechanism involving competition with intracellular calcium.

Cite This Study

Birks et al. (1968) studied this question.

synapsesocial.com/papers/6a71c71031a3df824329cee6 https://doi.org/10.1098/rspb.1968.0047

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