Population
Isolated canine and human coronary arteries in organ baths. Human coronary rings were isolated from 7…
Design
Preclinical
Authors
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Canine coronary data should not guide human therapy; leaves open differential endothelial modulation of serotonin versus acetylcholine in human vessels.
This preclinical study demonstrates significant species differences in coronary artery responses to acetylcholine and serotonin, highlighting that human coronary responses are less modulated by endothelial function for acetylcholine compared to serotonin.
Berkenboom et al. (1989) studied this question.
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