Key result
Essential hypertension in young patients was associated with a higher prevalence of >10 white matter lesions compared to normotensive controls (23% vs 0%).
Why the study?
Is essential hypertension in young patients associated with silent cerebrovascular damage and altered cerebrovascular reactivity compared to normotensive controls?
Observational (n=93)
Is essential hypertension in young patients associated with silent cerebrovascular damage and altered cerebrovascular reactivity compared to normotensive controls?
Absolute Event Rate: 23% vs 0%
Young patients with essential hypertension exhibit early signs of silent cerebrovascular damage, which correlates with disease duration and blunted nocturnal blood pressure dipping.
May signal early silent brain injury in young hypertensives; leaves open whether BP control alters lesion progression.
This study tested the association between cognitive functions, cerebrovascular damage, and cerebrovascular reactivity in 71 essential young hypertensives (age matched) and 22 normotensives (age matched). They underwent ambulatory blood pressure monitoring, neurocognitive tests, cerebral magnetic resonance, and transcranial Doppler. Twenty-three percent of patients showed more than 10 white matter lesions and 8% showed none. No control subjects showed more than 10 white matter lesions and 90% of normal controls showed no lesions. Patients with more than 10 white matter alterations had longer hypertensive story and showed significant lower nocturnal blood pressure fall. Pulsatility index was correlated with the number of white matter lesions.
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Paglieri et al. (2012) conducted an observational in Essential hypertension (n=93). Essential hypertension vs. Normotensive controls was evaluated on Presence of more than 10 white matter lesions. Essential hypertension in young patients was associated with a higher prevalence of >10 white matter lesions compared to normotensive controls (23% vs 0%).
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