Key result
The G allele of the SCN5A-H558R polymorphism was an independent risk factor for atrial fibrillation in Tibetans living at both middle (OR 2.344) and high altitudes (OR 2.921).
Why the study?
Data are limited on the associations between genetic polymorphisms, including SCN5A-H558R, and atrial fibrillation among populations living at different altitudes.
Is the SCN5A-H558R polymorphism associated with atrial fibrillation in Tibetans living at different altitudes?
Observational (n=426)
No
Is the SCN5A-H558R polymorphism associated with atrial fibrillation in Tibetans living at different altitudes?
Odds Ratio: 2.921 (95% CI 1.417–6.021)
p-value: p=0.004
The G allele of the SCN5A-H558R polymorphism is an independent risk factor for atrial fibrillation in Tibetans at both middle and high altitudes.
SCN5A-H558R G allele was associated with AF risk independent of altitude in Tibetans; leaves open confirmation in larger prospective cohorts.
Several studies have found associations of genes with atrial fibrillation (AF), including SCN5A-H558R. However, there are limited data of these associations among populations living at different altitudes. We investigated the relationship between the SCN5A-H558R polymorphism and AF in Tibetans living at different altitudes in Qinghai, China. General clinical and genotype data were obtained from 72 patients with AF and 109 non-AF (NAF) individuals at middle altitudes, and from 102 patients with AF and 143 NAF individuals at high altitudes. Multifactor logistic regression was performed to determine associations and AF risk factors. SCN5A-H558R genotypes differed significantly between the AF and NAF groups (P < .0125) and the G allele was an independent AF risk factor (P < .05) at both altitudes, with no significant differences according to altitude (P > .0125). At middle altitudes, age, red blood cell distribution width (RDW-SD), left atrial internal diameter (LAD), and G allele were independent AF risk factors. At high altitudes, age, smoking, hypertension, RDW-SD, free triiodothyronine, LAD, and G allele were independent AF risk factors (P < .05). The G allele of SCN5A-H558R might be an independent risk factor of AF both high and middle altitude, but there are some differences in other clinical risk factors of AF.
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An et al. (2022) conducted an observational in Atrial Fibrillation (n=426). SCN5A-H558R polymorphism (G allele) vs. A allele / Non-carriers was evaluated on Atrial fibrillation occurrence (High altitude group) (OR 2.921, 95% CI 1.417-6.021, p=0.004). The G allele of the SCN5A-H558R polymorphism was an independent risk factor for atrial fibrillation in Tibetans living at both middle (OR 2.344) and high altitudes (OR 2.921).
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