Why the study?
Does the addition of a beta-blocker reduce blood pressure and suppress the renin-angiotensin system in patients with essential hypertension insufficiently controlled on thiazide diuretics?
Population
16 patients, median age 41 years, with essential hypertension insufficiently controlled on…
Comparison
Addition of a beta-blocker for 3 months. vs Baseline (patients on hydrochlorothiazide alone).
Design
Cohort
Follow-up
3 months
Authors
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May support beta-blocker addition to thiazides for BP and RAS effects; leaves open need for RCTs on outcomes.
Does the addition of a beta-blocker reduce blood pressure and suppress the renin-angiotensin system in patients with essential hypertension insufficiently controlled on thiazide diuretics?
The addition of a beta-blocker to thiazide therapy in patients with essential hypertension suppresses thiazide-induced stimulation of the renin-angiotensin system and significantly reduces blood pressure.
Ibsen et al. (1980) studied this question.
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