Why the study?
Does the responsiveness of the renin-angiotensin system determine the blood pressure response to thiazide treatment in mild essential hypertension?
Population
25 patients with mild essential hypertension, aged 40 years (born in 1936).
Comparison
Hydrochlorothiazide and acute saralasin infusion. vs Baseline and 40-year-old control subjects.
Design
Cohort
Follow-up
3 months
Authors
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May link RAS responsiveness to variable thiazide response; hypothesis-generating and requires prospective confirmation before practice change.
Does the responsiveness of the renin-angiotensin system determine the blood pressure response to thiazide treatment in mild essential hypertension?
The responsiveness of the renin-angiotensin system counterbalances the hypotensive effect of thiazides in a subset of patients, determining the overall blood pressure response to treatment.
Ibsen et al. (1979) studied this question.
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