Why the study?
Does arterial stiffening sufficiently explain the age-related emergence of primary hypertension in a computational model?
Population
Empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and…
Comparison
Simulated age-dependent arterial stiffening… vs Simulated younger age groups with normal…
Design
Preclinical
Authors
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Arterial stiffening may drive age-related hypertension in models; hypothesis-generating and requires human validation before clinical consideration.
Does arterial stiffening sufficiently explain the age-related emergence of primary hypertension in a computational model?
A computational model demonstrates that age-related arterial stiffening alone is sufficient to explain the emergence of primary hypertension by misinforming the baroreflex system.
Pettersen et al. (2014) studied this question.
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