Why the study?
Aortic stiffening has emerged as a cause of age-related hypertension, making an understanding of its pathogenesis important for preventing and controlling hypertension.
Understanding the pathogenesis of aortic stiffness is a crucial approach for preventing and controlling age-related hypertension.
Aortic stiffness merits attention in older adults with hypertension; hypothesis-generating for targeted prevention pending prospective trials.
: Hypertension is a worldwide known cause of morbidity and mortality in the elderly and is a major risk factor for cardiovascular complications such as stroke, myocardial infarction, renal complications and heart failure. Although the mechanisms of hypertension remain largely unknown, a recent new concept is that aortic stiffening is a cause of hypertension in middle-aged and older individuals, which highlighted the importance of aortic stiffening in the development of age-related hypertension. Understanding the pathogenesis of aortic stiffness therefore became one of the important approaches to preventing and controlling hypertension. This review discusses the recent progress of the potential causes of aortic stiffening and its implication on the pathogenesis of hypertension, in terms of aging, inflammation, metabolic syndromes, neuroendocrine and the interaction among these causes.
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Onuh et al. (2020) studied this question.
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