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January 1, 1989Journal of Hypertension

Increased beta-adrenergic tone enhances arterial compliance in hyperkinetic borderline hypertension

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Why the study?

Does intravenous propranolol alter arterial compliance differently in patients with hyperkinetic versus normokinetic borderline hypertension?

Population

58 patients with borderline hypertension, comprising 32 with high cardiac output and 26 control subjects…

Comparison

0.2 mg/kg intravenous propranolol vs Baseline measurements and comparison between…

Design

Cross-sectional

Follow-up

Acute

Authors

JPJurij PétrinBEBrent M. EganSJStevo Juliust

Discussion

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Overview

Supports beta-adrenergic mediation of compliance differences; hypothesis-generating for targeted beta-blockade in hyperkinetic borderline hypertension.

Structured PICO

Does intravenous propranolol alter arterial compliance differently in patients with hyperkinetic versus normokinetic borderline hypertension?

P
Population
58 patients with borderline hypertension, comprising 32 with high cardiac output (hyperkinetic) and 26 control subjects with normokinetic borderline hypertension.
I
Intervention
0.2 mg/kg intravenous propranolol
C
Comparator
Baseline measurements (before propranolol) and comparison between hyperkinetic and normokinetic groups
O
Outcome
Arterial compliance assessed by the stroke volume-pulse pressure relationshipsurrogate

Disparities in vascular beta-adrenergic tone likely contribute to differences in arterial compliance between hyperkinetic and normokinetic borderline hypertensive patients.

Cite This Study

Pétrin et al. (1989) studied this question.

synapsesocial.com/papers/6a720896ac440176ef2a7b2dhttps://doi.org/10.1097/00004872-198900076-00035
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