Why the study?
Does intrarenal transfer of an intracellular fluorescent fusion of angiotensin II selectively in proximal tubules increase blood pressure in rats and mice?
Does intrarenal transfer of an intracellular fluorescent fusion of angiotensin II selectively in proximal tubules increase blood pressure in rats and mice?
Proximal tubule-selective transfer of an intracellular ANG II fusion protein increases blood pressure by activating AT1a receptors and increasing sodium reabsorption, highlighting the role of intracellular ANG II in blood pressure regulation.
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Proximal tubule intracellular ANG II may raise BP via AT1a in rodents; extends mechanistic insights but leaves open human translation.
Li et al. (2011) studied this question.
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