Structure–activity relationship expansion and microsomal stability assessment of the 2-morpholinobenzoic acid scaffold as antiproliferative phosphatidylcholine-specific phospholipase C inhibitors

Novel analogues of PC-PLC inhibitors were studied, with the 1-acyl-2-morpholino-5- N -benzylamine central scaffold found to be the optimal pharmacophore. This family demonstrates a high degree of stability following treatment with rat microsomes.