Why the study?
Do ACE inhibitors improve left ventricular morphology and function more than calcium antagonists in patients with essential hypertension and LVH?
Population
33 patients with essential hypertension and left ventricular hypertrophy (LVH)
Comparison
ACE inhibitors for 6 months vs Calcium antagonists for 6 months
Design
Cohort
Follow-up
6 months
Authors
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ACE inhibitors may confer greater LV functional benefits than calcium antagonists in hypertensive LVH; hypothesis-generating and requires randomized confirmation.
Do ACE inhibitors improve left ventricular morphology and function more than calcium antagonists in patients with essential hypertension and LVH?
In patients with essential hypertension and LVH, ACE inhibitors improve left ventricular systolic and diastolic function more than calcium antagonists, despite similar reductions in blood pressure and LV mass.
Matsuzaki et al. (1997) studied this question.
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