Why the study?
Are renin-angiotensin system genetic polymorphisms associated with salt sensitivity in patients with essential hypertension?
Population
50 patients with essential hypertension
Comparison
High salt intake and determination of… vs Comparison between different genotypes
Design
Cohort
Authors
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ACE II genotype associated with salt sensitivity; hypothesis-generating for personalized management, pending prospective validation.
Are renin-angiotensin system genetic polymorphisms associated with salt sensitivity in patients with essential hypertension?
The insertion/deletion polymorphism of the ACE gene is significantly associated with salt-sensitive hypertension, with the II and DI genotypes conferring a higher prevalence of salt sensitivity compared to the DD genotype.
Giner et al. (2000) studied this question.
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