Why the study?
Is the ACE gene I/D polymorphism associated with salt sensitivity in Japanese patients with essential hypertension?
Population
66 Japanese patients with essential hypertension
Comparison
Angiotensin I-converting enzyme gene 287-bp… vs ACE gene genotypes ID and DD
Design
Cohort
Follow-up
2 weeks (1 week low salt diet, 1 week high salt diet)
Authors
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ACE I/D I allele links to salt sensitivity in Japanese hypertensives; hypothesis-generating and requires validation before any clinical application.
Is the ACE gene I/D polymorphism associated with salt sensitivity in Japanese patients with essential hypertension?
The ACE gene I/D polymorphism is a genetic factor associated with salt sensitivity of blood pressure in Japanese patients with essential hypertension, independent of plasma renin activity.
Hiraga et al. (1996) studied this question.
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